Roflumilast, an oral, once a day anti-inflammatory agent, improves lung function and reduces exacerbations in patients with chronic obstructive pulmonary disease (COPD) who have chronic respiratory symptoms and are at greater risk of exacerbations. The effect persists even when roflumilast is added to conventional treatment with inhaled long-acting bronchodilators. Thus, roflumilast therapy has the potential to become an important treatment for these patients.
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